The main focus of RE is that of a pharmaceutical company known as the Umbrella Corporation.
Umbrella is featured as a very powerful company that does research on virus prevention (or use), and even has their own military type force.
For most of us, we know that Umbrella already does these things. But how were they founded?
Umbrella was founded in 1968 by Lord Oswell E. Spencer; Sir Edward Ashford and Dr. James Marcus after the discovery of the Progenitor virus the previous year. Another starting member, though not considered a co-founder, was Marcus' student Brandon Bailey, who was with Marcus and Spencer when they first discovered the Stairway of the Sun flower.
Shortly after Umbrella's founding, Ashford died from exposure to the virus, and Brandon was effectively-exiled to the Umbrella Africa Laboratory, where he send virus samples to Dr. Marcus' newly built research center.
In 1969, Edward's son Alexander began the construction of the Antarctic Base, attached to which was a research centre where he began development of his "Code: Veronica" project. This was his research into the gene that controls intelligence. Two years later, Alfred and Alexia would be born from his research.
Seeking new information on Progenitor, Marcus had several of his students infected with the virus. They were however, unable to survive its effects and died, their corpses dumped in the Water Treatment facility.
Marcus injected leeches with Progenitor in 1978, and bore witness to the creation of a new strain which he named the "Tyrant virus". Later this year, the Training facility would be closed and Marcus' two prized students: Albert Wesker and William Birkin, would be moved to the nearby Arklay Laboratory.
Yet again in 1978, did Marcus find evidence of tampering. In his increasing paranoia brought on by his quest for glory and isolation from mankind, he wrote in his diary that Albert and William were the only humans he trusted. His trust in them would betray him ten years later however, as the two would - under direct orders from Spencer, himself - have him assassinated by a Special forces unit and dumped in the Water Treatment Facility. Credit for "t" would be taken by William. His trust in William would also render hiding the source of "t" - the Leeches - useless.
By now however, Birkin had little care for "t", having discovered the G-virus in the body of Lisa Trevor, the daughter of George, still kept in the estate as a guinea pig for their twisted experiments.
This of course, lay the foundaitons of chaos as the estate would be infected by marcus and bring to the mansuon, then the city, then the world! The ultimate nighmare!